Inhibition mechanism and molecular modeling studies of the interactions of 6- (propan-2-yl)-3-methyl-morpholine-2,5-dione with xanthine oxidase
نویسندگان
چکیده
1Center for Biomedicinal Science, Faculty of Medicine, University of Niš, Bulevar Dr Zorana Djindjica 81, 18000 Niš, Serbia 2Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Build. 9, 1113 Sofia, Bulgaria 3Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria 4Institute of Biochemistry, Faculty of Medicine, University of Niš, Bulevar Dr Zorana Djindjica 81, 18000 Niš, Serbia 5Faculty of Technology, University of Niš, Bulevar Oslobodjenja 124, 16000 Leskovac, Serbia
منابع مشابه
2-[(3R,6R)-6-Methyl-2,5-dioxomorpholin-3-yl]-N-(propan-2-yl)acetamide
The molecular conformation of the title compound, C(10)H(16)N(2)O(4), is determined by an intra-molecular N-H⋯O hydrogen bond involving the morpholine NH group and the amide O atom. In the crystal, mol-ecules are linked by N-H⋯O hydrogen bonds into chains along the a-axis direction.
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